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Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging

Title data

Pfaff, André ; Schallon, Anja ; Ruhland, Thomas M. ; Majewski, Alexander P. ; Schmalz, Holger ; Freitag, Ruth ; Müller, Axel H. E.:
Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging.
In: Biomacromolecules. Vol. 12 (2011) Issue 10 . - pp. 3805-3811.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm201051p

Project information

Project financing: European Science Foundation

Abstract in another language

The synthesis of galactose-displaying core-shell exhibiting and magnetic properties by grafting a glycocopolymer consisting of 6-O-methacryloylgalactopyranose (MAGal) and 4-(pyrenyl)butynl methacrylate (PyMA) onto magnetic silica particles via thiol-ene chemistry is reported Magnetization measurements indicated that neither the encapsulation of the iron oxide particles into silica nor the grafting of the glycocopolymer chains had a significant influence on the superparamagnetic properties. This not only simplifies the purification of the particles but may facilitate the use of the particles in applications such as hyperthermia or magnetic resonance imaging (MRI). Furthermore, the hydrophilic glycopolymer shell provided solubility of the particles in aqueous medium and enabled the uptake of the particles into the cytoplasm and nucleus of lung cancer cells via carbohydrate-lectin recognition effects.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: ISI:000295602600050
PMID: 21875143
Keywords: IRON-OXIDE NANOPARTICLES; QUANTUM DOTS; SURFACE MODIFICATION; LIVE CELLS; MICROSPHERES; CORE; CHEMISTRY; SHELL; CRYSTALLINE; DERIVATIVES
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 14 Apr 2015 07:00
Last Modified: 17 Apr 2018 07:04
URI: https://eref.uni-bayreuth.de/id/eprint/10069