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Molecular details of cAMP generation in mammalian cells : a tale of two systems.

Title data

Kamenetsky, Margarita ; Middelhaufe, Sabine ; Bank, Erin M. ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
In: Journal of Molecular Biology. Vol. 362 (29 September 2006) Issue 4 . - pp. 623-639.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.07.045

Abstract in another language

The second messenger cAMP has been extensively studied for half a century, but the plethora of regulatory mechanisms controlling cAMP synthesis in mammalian cells is just beginning to be revealed. In mammalian cells, cAMP is produced by two evolutionary related families of adenylyl cyclases, soluble adenylyl cyclases (sAC) and transmembrane adenylyl cyclases (tmAC). These two enzyme families serve distinct physiological functions. They share a conserved overall architecture in their catalytic domains and a common catalytic mechanism, but they differ in their sub-cellular localizations and responses to various regulators. The major regulators of tmACs are heterotrimeric G proteins, which transduce extracellular signals via G protein-coupled receptors. sAC enzymes, in contrast, are regulated by the intracellular signaling molecules bicarbonate and calcium. Here, we discuss and compare the biochemical, structural and regulatory characteristics of the two mammalian AC families. This comparison reveals the mechanisms underlying their different properties but also illustrates many unifying themes for these evolutionary related signaling enzymes.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 12747789
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 14 Apr 2015 10:33
Last Modified: 14 Apr 2015 10:33
URI: https://eref.uni-bayreuth.de/id/eprint/10140