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MYB10 and MYB72 are required for growth under iron-limiting conditions

Title data

Palmer, Christine M. ; Hindt, Maria N. ; Schmidt, Holger ; Clemens, Stephan ; Guerinot, Mary Lou:
MYB10 and MYB72 are required for growth under iron-limiting conditions.
In: PLoS Genetics. Vol. 9 (2013) Issue 11 . - e1003953.
ISSN 1553-7404
DOI: https://doi.org/10.1371/journal.pgen.1003953

Abstract in another language

Iron is essential for photosynthesis and is often a limiting nutrient for plant productivity. Plants respond to conditions of irondeficiency by increasing transcript abundance of key genes involved in iron homeostasis, but only a few regulators of thesegenes have been identified. Using genome-wide expression analysis, we searched for transcription factors that are inducedwithin 24 hours after transferring plants to iron-deficient growth conditions. Out of nearly 100 transcription factors shownto be up-regulated, we identified MYB10 and MYB72 as the most highly induced transcription factors. Here, we show thatMYB10 and MYB72 are functionally redundant and are required for plant survival in alkaline soil where iron availability isgreatly restricted. myb10myb72 double mutants fail to induce transcript accumulation of the nicotianamine synthase geneNAS4. Both myb10myb72 mutants and nas4-1 mutants have reduced iron concentrations, chlorophyll levels, and shoot massunder iron-limiting conditions, indicating that these genes are essential for proper plant growth. The double myb10myb72mutant also showed nickel and zinc sensitivity, similar to the nas4 mutant. Ectopic expression of NAS4 rescues myb10myb72plants, suggesting that loss of NAS4 is the primary defect in these plants and emphasizes the importance of nicotianamine,an iron chelator, in iron homeostasis. Overall, our results provide evidence that MYB10 and MYB72 act early in the irondeficiencyregulatory cascade to drive gene expression of NAS4 and are essential for plant survival under iron deficiency.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: BAYCEER119258
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Plant Physiology
Research Institutions > Research Centres > Bayreuth Center of Ecology and Environmental Research- BayCEER
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: Yes
DDC Subjects: 500 Science
Date Deposited: 29 Apr 2015 15:41
Last Modified: 08 May 2015 11:08
URI: https://eref.uni-bayreuth.de/id/eprint/11612