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Control of Drug Loading and Release Properties of Spider Silk Sub-Microparticles


Blüm, Claudia ; Scheibel, Thomas:
Control of Drug Loading and Release Properties of Spider Silk Sub-Microparticles.
In: BioNanoScience. Bd. 2 (2012) Heft 2 . - S. 67-74.
ISSN 2191-1649
DOI: https://doi.org/10.1007/s12668-012-0036-7


The controlled delivery of water-soluble substances is one important issue in pharmaceutical and medical applications. Biocompatible polymers which can easily be processed in an all aqueous process with controllable and adjustable properties have been thoroughly investigated in the past for their use as drug delivery vehicles. Recently, we established sub-microparticles produced from the engineered spider silk protein eADF4(C16) as potential carriers for highly water-soluble drugs. Here, we investigate the influence of crosslinking on the structural integrity of the sub-microparticles and the effect on drug loading and release. To analyze the order-of-addition influences of processing of sub-microparticles on drug loading and release, we tested five different preparation routes. We showed that the preparation route largely influences the loading capacity of the eADF4(C16) submicroparticles.In the preferred preparation route, rhodamine B and the protein are co-precipitated by salting-out,yielding the highest loading. Further, crosslinking the proteins with APS (ammonium persulfate) and Rubpy (Tris(2,2′- bipyridyl)dichlororuthenium(II)) has an impact on loading as well as on the release behavior of drug molecules as shown exemplarily with rhodamine B.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Zusätzliche Informationen: Artikel erschien zunächst online am 02.02.2012
Keywords: Drug delivery; Crosslinking; Recombinant spider silk protein; Particles
Institutionen der Universität: Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien > Lehrstuhl Biomaterialien - Univ.-Prof. Dr. Thomas Scheibel
Profilfelder > Advanced Fields > Neue Materialien
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Profilfelder > Advanced Fields > Polymer- und Kolloidforschung
Profilfelder > Emerging Fields > Lebensmittel- und Gesundheitswissenschaften
Profilfelder > Advanced Fields
Profilfelder > Emerging Fields
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Eingestellt am: 08 Okt 2015 13:19
Letzte Änderung: 26 Nov 2015 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/15583