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Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship

Title data

Davidov, Geula ; Müller, Frank-Dietrich ; Baumgartner, Jens ; Bitton, Ronit ; Faivre, Damien ; Schüler, Dirk ; Zarivach, Raz:
Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship.
Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel; Department of Microbiology, University of Bayreuth, Bayreuth, Germany; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces (MPI), Potsdam, Germany; Department of Chemical Engineering, Ilse Katz Institute for Nanoscale Science and Technology, Ben Gurion University of the Negev, Beer-Sheva, Israel
In: Frontiers in Molecular Biosciences. Vol. 2 (21 May 2015) . - pp. 1-13.
ISSN 2296-889X
DOI: https://doi.org/10.3389/fmolb.2015.00025

Abstract in another language

Magnetotactic bacteria (MTB) are a diverse group of aquatic bacteria that have the magnetotaxis ability to align themselves along the geomagnetic field lines and to navigate to a microoxic zone at the bottom of chemically stratified natural water. This special navigation is the result of a unique linear assembly of a specialized organelle, the magnetosome, which contains a biomineralized magnetic nanocrystal enveloped by a cytoplasmic membrane. The Magnetospirillum gryphiswaldense MtxA protein (MGR_0208) was suggested to play a role in bacterial magnetotaxis due to its gene location in an operon together with putative signal transduction genes. Since no homology is found for MtxA, and to better understand the role and function of MtxA in MTBés magnetotaxis, we initiated structural and functional studies of MtxA via X-ray crystallography and deletion mutagenesis. Here, we present the crystal structure of the MtxA C-terminal domain and provide new insights into its sequence-structure relationship.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: MtxA; magnetotactic bacteria; magnetosome genomic island; magnetotaxis; magnetosome; tetratricopeptide repeats; immunoglobulin-like domain
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology > Chair Microbiology - Univ.-Prof. Dr. Dirk Schüler
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 500 Natural sciences
500 Science > 570 Life sciences, biology
Date Deposited: 01 Dec 2016 12:46
Last Modified: 01 Dec 2016 12:46
URI: https://eref.uni-bayreuth.de/id/eprint/18131