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Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship

Titelangaben

Davidov, Geula ; Müller, Frank-Dietrich ; Baumgartner, Jens ; Bitton, Ronit ; Faivre, Damien ; Schüler, Dirk ; Zarivach, Raz:
Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship.
Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel; Department of Microbiology, University of Bayreuth, Bayreuth, Germany; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces (MPI), Potsdam, Germany; Department of Chemical Engineering, Ilse Katz Institute for Nanoscale Science and Technology, Ben Gurion University of the Negev, Beer-Sheva, Israel
In: Frontiers in Molecular Biosciences. Bd. 2 (21 Mai 2015) . - S. 1-13.
ISSN 2296-889X
DOI: https://doi.org/10.3389/fmolb.2015.00025

Abstract

Magnetotactic bacteria (MTB) are a diverse group of aquatic bacteria that have the magnetotaxis ability to align themselves along the geomagnetic field lines and to navigate to a microoxic zone at the bottom of chemically stratified natural water. This special navigation is the result of a unique linear assembly of a specialized organelle, the magnetosome, which contains a biomineralized magnetic nanocrystal enveloped by a cytoplasmic membrane. The Magnetospirillum gryphiswaldense MtxA protein (MGR_0208) was suggested to play a role in bacterial magnetotaxis due to its gene location in an operon together with putative signal transduction genes. Since no homology is found for MtxA, and to better understand the role and function of MtxA in MTBés magnetotaxis, we initiated structural and functional studies of MtxA via X-ray crystallography and deletion mutagenesis. Here, we present the crystal structure of the MtxA C-terminal domain and provide new insights into its sequence-structure relationship.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: MtxA; magnetotactic bacteria; magnetosome genomic island; magnetotaxis; magnetosome; tetratricopeptide repeats; immunoglobulin-like domain
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Mikrobiologie > Lehrstuhl Mikrobiologie - Univ.-Prof. Dr. Dirk Schüler
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Mikrobiologie
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik
500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 01 Dec 2016 12:46
Letzte Änderung: 01 Dec 2016 12:46
URI: https://eref.uni-bayreuth.de/id/eprint/18131