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Biofabrication of 3D constructs : fabrication technologies and spider silk proteins as bioinks

Title data

DeSimone, Elise ; Schacht, Kristin ; Jungst, Thomasz ; Groll, Jürgen ; Scheibel, Thomas:
Biofabrication of 3D constructs : fabrication technologies and spider silk proteins as bioinks.
In: Pure and Applied Chemistry. Vol. 87 (July 2015) Issue 8 . - pp. 737-749.
ISSN 1365-3075
DOI: https://doi.org/10.1515/pac-2015-0106

Abstract in another language

Despite significant investment in tissue engineering over the past 20 years, few tissue engineered products have made it to market. One of the reasons is the poor control over the 3D arrangement of the scaffold’s components. Biofabrication is a new field of research that exploits 3D printing technologies with high spatial resolution for the simultaneous processing of cells and biomaterials into 3D constructs suitable for tissue engineering. Cell-encapsulating biomaterials used in 3D bioprinting are referred to as bioinks. This review consists of: (1) an introduction of biofabrication, (2) an introduction of 3D bioprinting, (3) the requirements of bioinks, (4) existing bioinks, and (5) a specific example of a recombinant spider silk bioink. The recombinant spider silk bioink will be used as an example because its unmodified hydrogel format fits the basic requirements of bioinks: to be printable and at the same time cytocompatible. The bioink exhibited both cytocompatible (self-assembly, high cell viability) and printable (injectable, shear-thinning, high shape fidelity) qualities. Although improvements can be made, it is clear from this system that, with the appropriate bioink, many of the existing faults in tissue-like structures produced by 3D bioprinting can be minimized.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biofabrication; bioink; biomaterials; biomedical applications; 3D bioprinting; biotechnology; NICE-2014; spider silk
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 13 Oct 2015 07:28
Last Modified: 27 Jul 2016 13:03
URI: https://eref.uni-bayreuth.de/id/eprint/20190