bei Google ScholarTitelangaben
Wiegand, C. ; Pflugmacher, S. ; Giese, M. ; Frank, Hartmut ; Steinberg, C.:
Uptake, toxicity, and effects on detoxication enzymes of atrazine and trifluoroacetate in embryos of zebrafish.
In: Ecotoxicology and Environmental Safety.
Bd. 45
(2000)
Heft 2
.
- S. 122-131.
ISSN 1090-2414
DOI: https://doi.org/10.1006/eesa.1999.1845
Abstract
The uptake, toxicity, and elimination of atrazine and trifluoroacetate (TFA) were studied in early life stages of the zebrafish (Danio rerio). Furthermore, the effects of these xenobiotics on soluble (s) and microsomal (m) glutathione S-transferases (GST) of zebrafish embryos were investigated using 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), and [C-14]atrazine. [C-14]Atrazine was taken up by the embryos within seconds, unhindered by the chorions. It accumulated in the embryos by a factor of 19 after 24 h of exposure time. LC50, (48 h) was determined at 36.8 mg/L. At a level of 5 mg/L atrazine, activities of s and m GSTs,were elevated in most stages, especially in prim 6 and long pec stage (24, 48 h after fertilization, respectively). GST activity toward atrazine was detectable only in untreated D. rerio eggs, increasing with developmental time. [C-14]Atrazine was eliminated from the embryos between 24 and 48 h, indicating a possible metabolism to a more hydrophilic GSH conjugate. [C-14]TFA was taken up by embryos, reaching at maximum fivefold the concentration of the incubation medium after 10 h. The chorions served no physiological protection. TFA (1 g/L) caused low elevation of the GST activity. No acute toxic effects (48 h) were observed up to 4 g/L TFA. (C) 2000 Academic Press
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Zusätzliche Informationen: | BAYCEER33901 |
| Institutionen der Universität: | Forschungseinrichtungen > Forschungszentren > Bayreuther Zentrum für Ökologie und Umweltforschung - BayCEER Forschungseinrichtungen Forschungseinrichtungen > Forschungszentren |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik |
| Eingestellt am: | 12 Feb 2016 07:15 |
| Letzte Änderung: | 12 Feb 2016 07:15 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/30638 |