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Recombinant Adenoviruses for In Vivo Expression of Antibody Fragments

Titelangaben

Kontermann, Roland E. ; Korn, Tina ; Jérôme, Valérie:
Recombinant Adenoviruses for In Vivo Expression of Antibody Fragments.
In: Welschof, Martin ; Krauss, Jürgen (Hrsg.): Recombinant Antibodies for Cancer Therapy : Methods and Protocols. - Totowa, NJ : Humana Press , 2003 . - S. 421-433 . - (Methods in Molecular Biology ; 207 )
ISBN 978-1-59259-334-7
DOI: https://doi.org/10.1385/1-59259-334-8:421

Volltext

Link zum Volltext (externe URL): Volltext

Abstract

A growing number of recombinant antibodies is being developed for immunotherapy of cancer (1,2) (see also Chapter 2). Although these recombinant antibodies can exhibit a potent anti-tumoral activity in vitro, efficacy in vivo is often limited by the short serum half-life of these molecules. Thus, repeated or continuous administrations are required to obtain a sufficiently high serum concentration. An alternative approach to the injection of the therapeutic molecules is the expression and secretion of these proteins in vivo, which leads to high levels of the molecules in the serum (3–6). Furthermore, this approach obviates the need for the preparation of bulk amounts of pure protein. Recombinant adenoviruses are widely used vectors for the delivery of a transgene in gene therapy (7). Recently, it was demonstrated that an anti-carcinoembryonic antigen (CEA) scFv-granulocyte/monocyte colony-stimulating factor (GM-CSF) fusion protein is expressed in vivo for a prolonged period of time after intravenous injection of recombinant adenoviruses (8).

Weitere Angaben

Publikationsform: Aufsatz in einem Buch
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Bioprozesstechnik
Fakultäten
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik
500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
Eingestellt am: 26 Feb 2016 10:37
Letzte Änderung: 26 Feb 2016 10:37
URI: https://eref.uni-bayreuth.de/id/eprint/31077