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Foams made of enigneered recombinant Spider Silk Proteins as 3D Scaffolds for Cell Growth

Title data

Schacht, Kristin ; Vogt, Jessica ; Scheibel, Thomas:
Foams made of enigneered recombinant Spider Silk Proteins as 3D Scaffolds for Cell Growth.
In: ACS Biomaterials Science & Engineering. (4 March 2016) .
ISSN 2373-9878
DOI: https://doi.org/10.1021/acsbiomaterials.5b00483

Abstract in another language

Materials for tissue engineering have to be biocompatible and have to support cell adhesion, proliferation and differentiation. Additionally, in case of soft tissue engineering the mechanical properties have to accommodate that of the tissue with mechanical integrity until the artificial scaffold is replaced by natural extracellular matrix. In case of artificial 3D scaffolds, it is of critical importance to be able to tune the mechanical properties, the inner free volume (i.e., pore size) and degradation behavior of the employed biomaterial. Here, the potential of recombinant spider silk proteins was evaluated concerning their processing into and application as 3D scaffolds for soft tissue engineering. Highly porous foams made of the recombinant spider silk protein eADF4(C16) and a variant containing an RGD motif were fabricated by salt leaching yielding mechanically robust scaffolds. In contrast to other salt-leached silk scaffolds, the swelling behavior of these scaffolds was low, and the mechanical properties in the range of soft tissues. The pore size and porosity of the foams could be adjusted by the salt crystal size. Fibroblasts adhered and proliferated well in foams made of the spider silk RGD variant but not in the foams of the nonmodified one.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: recombinant spider silk proteins; salt leaching; foams; porous scaffolds; biomedical applications; tissue engineering
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 18 Mar 2016 08:23
Last Modified: 18 Mar 2016 08:23
URI: https://eref.uni-bayreuth.de/id/eprint/31891