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Controlled Retention and Release of Biomolecular Transport Systems Using Shape-Changing Polymer Bilayers

Titelangaben

Stoychev, Georgi ; Reuther, Cordula ; Diez, Stefan ; Ionov, Leonid:
Controlled Retention and Release of Biomolecular Transport Systems Using Shape-Changing Polymer Bilayers.
In: Angewandte Chemie International Edition. Bd. 55 (23 Dezember 2016) Heft 52 . - S. 16106-16109.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201608299

Abstract

Biomolecular transport systems based on cytoskeletal filaments and motor proteins have become promising tools for a wide range of nanotechnological applications. In this paper, we report control of such transport systems using substrates with switchable shape. We demonstrate this approach on the example of microtubules gliding on surfaces of self-folding polymer bilayers with adsorbed kinesin motors. The polymer bilayers are able to undergo reversible transitions between flat and tube-like shapes that allow the externally controlled retention and release of gliding microtubules. The demonstrated approach, based on surfaces with reconfigurable topography, opens broad perspectives to control biomolecular transport systems for bioanalytical and sensing applications, as well as for the construction of subcellular compartments in the field of synthetic biology.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: biomolecular transport; hydrogels; motor proteins; self-folding
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation > Professur Biofabrikation - Univ.-Prof. Dr. Leonid Ionov
Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 20 Jun 2017 11:12
Letzte Änderung: 20 Jun 2017 11:12
URI: https://eref.uni-bayreuth.de/id/eprint/37689