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Controlled Retention and Release of Biomolecular Transport Systems Using Shape-Changing Polymer Bilayers

Title data

Stoychev, Georgi ; Reuther, Cordula ; Diez, Stefan ; Ionov, Leonid:
Controlled Retention and Release of Biomolecular Transport Systems Using Shape-Changing Polymer Bilayers.
In: Angewandte Chemie International Edition. Vol. 55 (23 December 2016) Issue 52 . - pp. 16106-16109.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201608299

Abstract in another language

Biomolecular transport systems based on cytoskeletal filaments and motor proteins have become promising tools for a wide range of nanotechnological applications. In this paper, we report control of such transport systems using substrates with switchable shape. We demonstrate this approach on the example of microtubules gliding on surfaces of self-folding polymer bilayers with adsorbed kinesin motors. The polymer bilayers are able to undergo reversible transitions between flat and tube-like shapes that allow the externally controlled retention and release of gliding microtubules. The demonstrated approach, based on surfaces with reconfigurable topography, opens broad perspectives to control biomolecular transport systems for bioanalytical and sensing applications, as well as for the construction of subcellular compartments in the field of synthetic biology.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biomolecular transport; hydrogels; motor proteins; self-folding
Institutions of the University: Faculties > Faculty of Engineering Science > Professur Biofabrikation > Professur Biofabrikation - Univ.-Prof. Dr. Leonid Ionov
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Professur Biofabrikation
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 Jun 2017 11:12
Last Modified: 20 Jun 2017 11:12
URI: https://eref.uni-bayreuth.de/id/eprint/37689