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Rare-Earth Metal Cations Incorporated Silica Hybrid Nanoparticles Templated by Cylindrical Polymer Brushes

Title data

Zheng, Zhicheng ; Daniel, Alexander ; Yu, Wei ; Weber, Birgit ; Ling, Jun ; Müller, Axel H. E.:
Rare-Earth Metal Cations Incorporated Silica Hybrid Nanoparticles Templated by Cylindrical Polymer Brushes.
In: Chemistry of Materials. Vol. 25 (2013) Issue 22 . - pp. 4585-4594.
ISSN 1520-5002
DOI: https://doi.org/10.1021/cm402776d

Abstract in another language

A novel template-directed approach based on core–shell cylindrical polymer brushes (CPBs) has been developed to prepare rare-earth metal cations (Ln3+) incorporated silica hybrid nanoparticles (NPs) with predictable dimensions. Tight chelation of Ln3+ ions in the core of the CPB template and a cross-linked silica layer deposited on the shell provide a very stable encapsulation of Ln3+ ions within the hybrid NPs and thus a high biocompatibility. As expected, the silica hybrid NPs obtain unique and diverse properties from the incorporated Ln3+ ions. That is, the hybrid NPs with Tb3+ or Eu3+ incorporation exhibit characteristic photoluminescence in visible light range, while the Gd3+- and Tb3+-containing hybrid NPs show paramagnetic behavior. Especially, the Gd3+-containing silica hybrid NPs show a remarkable longitudinal relaxation time (T1) shortening effect as well as minimal cytotoxicity, suggesting the application potential of these NPs as effective magnetic resonance imaging (MRI) contrast agents. This novel template-directed approach succeeds in combining different functional centers via loading in situ mixed Ln3+ ions (e.g. Tb3+ and Gd3+) into individual CPBs resulting in multicomponent hybrid NPs, which possess both visible photoluminescence and T1 contrast enhancement and can thus be applied as multimodal bioimaging probes.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry IV > Chair Anorganic Chemistry IV - Univ.-Prof. Dr. Birgit Weber
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry IV
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 26 Jul 2017 11:55
Last Modified: 26 Jul 2017 11:55
URI: https://eref.uni-bayreuth.de/id/eprint/38822