Titlebar

Bibliografische Daten exportieren
Literatur vom gleichen Autor
plus auf ERef Bayreuth
plus bei Google Scholar

 

Hemoglobin concentration, total hemoglobin mass and plasma volume in patients : implications for anemia

Titelangaben

Otto, James M. ; Plumb, James O. M. ; Clissold, Eleri ; Kumar, Shriya ; Wakeham, Denis J. ; Schmidt, Walter ; Grocott, Michael P. W. ; Richards, Toby ; Montgomery, Hugh:
Hemoglobin concentration, total hemoglobin mass and plasma volume in patients : implications for anemia.
In: Haematologica. Bd. 102 (8 Juni 2017) Heft 9 . - S. 1477-1485.
ISSN 1592-8721
DOI: 10.3324/haematol.2017.169680

Abstract

In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l-1 in non-pregnant females and < 130 g.l-1 in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating total hemoglobin mass considered as a cause. But does this matter? We explored this issue in patients, using the optimized carbon-monoxide rebreathing method to measure hemoglobin concentration and thereby calculate plasma volume in healthy volunteers, surgical patients, and those with inflammatory bowel disease, chronic liver disease or heart failure. We studied 109 participants. Hemoglobin mass correlated well with its concentration in the healthy, surgical and inflammatory bowel disease groups (r= 0.687-0.871, p< 0.001). However, they were poorly related in liver disease (r= 0.410, p= 0.11) and heart failure patients (r= 0.312, p= 0.16). Here, hemoglobin mass explained little of the variance in its concentration (adjusted R2= 0.109 and 0.052; p= 0.11 and 0.16), whilst plasma volume did (R2 change 0.724 and 0.805 in heart and liver disease respectively, p<0.0001). Exemplar patients with identical (normal or raised) total hemoglobin masses were diagnosed as profoundly anemic (or not) depending on differences in plasma volume that had not been measured or even considered as a cause. The traditional inference that anemia generally reflects hemoglobin deficiency may be misleading, potentially resulting in inappropriate tests and therapeutic interventions to address 'hemoglobin deficiency not plasma volume excess. Measurement of total hemoglobin mass and plasma volume is now simple, cheap and safe, and its more routine use advocated.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft
Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie)
Fakultäten
Fakultäten > Kulturwissenschaftliche Fakultät
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
Eingestellt am: 07 Sep 2017 12:31
Letzte Änderung: 07 Sep 2017 12:31
URI: https://eref.uni-bayreuth.de/id/eprint/39245