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On the interplay of shell structure with low- and high-frequency mechanics of multifunctional magnetic microbubbles

Title data

Pöhlmann, Melanie ; Grishenkov, Dmitry ; Kothapalli, Satya V. V. N. ; Harmark, Johan ; Hebert, Hans ; Philipp, Alexandra ; Hoeller, Roland ; Seuss, Maximilian ; Kuttner, Christian ; Margheritelli, Silvia ; Paradossi, Gaio ; Fery, Andreas:
On the interplay of shell structure with low- and high-frequency mechanics of multifunctional magnetic microbubbles.
In: Soft Matter. Vol. 10 (2014) Issue 1 . - pp. 214-226.
ISSN 1744-6848
DOI: https://doi.org/10.1039/c3sm51560e

Official URL: Volltext

Abstract in another language

Polymer-shelled magnetic microbubbles have great potential as hybrid contrast agents for ultrasound and magnetic resonance imaging. In this work, we studied US/MRI contrast agents based on air-filled poly(vinyl alcohol)-shelled microbubbles combined with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are integrated either physically or chemically into the polymeric shell of the microbubbles (MBs). As a result, two different designs of a hybrid contrast agent are obtained. With the physical approach, SPIONs are embedded inside the polymeric shell and with the chemical approach SPIONs are covalently linked to the shell surface. The structural design of hybrid probes is important, because it strongly determines the contrast agent's response in the considered imaging methods. In particular, we were interested how structural differences affect the shell's mechanical properties, which play a key role for the MBs' US imaging performance. Therefore, we thoroughly characterized the MBs' geometric features and investigated low-frequency mechanics by using atomic force microscopy (AFM) and high-frequency mechanics by using acoustic tests. Thus, we were able to quantify the impact of the used SPIONs integration method on the shell's elastic modulus, shear modulus and shear viscosity. In summary, the suggested approach contributes to an improved understanding of structure--property relations in US- active hybrid contrast agents and thus provides the basis for their sustainable development and optimization.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 05 Dec 2014 10:27
Last Modified: 12 Feb 2015 11:55
URI: https://eref.uni-bayreuth.de/id/eprint/3928