Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Release Properties of Pressurized Microgel Templated Capsules

Title data

Schmidt, Stephan ; Fernandes, Paulo A. L. ; de Geest, Bruno G. ; Delcea, Mihaela ; Skirtach, Andre G. ; Möhwald, Helmuth ; Fery, Andreas:
Release Properties of Pressurized Microgel Templated Capsules.
In: Advanced Functional Materials. Vol. 21 (2011) Issue 8 . - pp. 1411-1418.
ISSN 1616-301X
DOI: https://doi.org/10.1002/adfm.201002200

Official URL: Volltext

Abstract in another language

Direction-specific release induced through osmotic pressure inside giant microcapsules is realized and monitored at high and low concentrations of encapsulated polymer. A clear correlation between the release kinetics upon opening the shell and encapsulated polymer concentration is observed. This has been independently confirmed by shell opening via nanoindentation and laser radiation. To quantify these observations, the internal pressure of the capsules is determined by analysis of mechanical tests performed via colloidal probe AFM. As expected, larger amounts of encapsulated material lead to increased internal pressures and enhanced release kinetics. The results show how drug release can be accelerated by encapsulation of osmotic pressure generating species. Such pressurized capsules systems show large ejection velocities and are envisioned as an inexpensive biolistic transfection device for in vitro applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 08 Dec 2014 07:17
Last Modified: 10 Feb 2015 12:30
URI: https://eref.uni-bayreuth.de/id/eprint/3975