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Nano-coating protects biofunctional materials

Title data

Tscheliessnig, Rupert ; Zörnig, Martin ; Herzig, Eva M. ; Lückerath, Katharina ; Altrichter, Jens ; Kemter, Kristina ; Paunel-Görgülü, Adana ; Lögters, Tim ; Windolf, Joachim ; Pabisch, Silvia ; Cinatl, Jindrich ; Rabenau, Holger F. ; Jungbauer, Alois ; Müller-Buschbaum, Peter ; Scholz, Martin ; Koch, Joachim:
Nano-coating protects biofunctional materials.
In: Materials Today. Vol. 15 (September 2012) Issue 9 . - pp. 394-404.
ISSN 1873-4103
DOI: https://doi.org/10.1016/S1369-7021(12)70166-9

Official URL: Volltext

Abstract in another language

The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Juniorprofessur Experimentalphysik VII - Dynamik und Strukturbildung > Juniorprofessur Experimentalphysik VII - Dynamik und Strukturbildung - Juniorprof. Dr. Eva Maria Herzig
Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Juniorprofessur Experimentalphysik VII - Dynamik und Strukturbildung
Result of work at the UBT: No
DDC Subjects: 500 Science > 530 Physics
Date Deposited: 06 Oct 2017 09:22
Last Modified: 06 Oct 2017 09:22
URI: https://eref.uni-bayreuth.de/id/eprint/39916