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On the mechanical stability of polymeric microcontainers functionalized with nanoparticles

Title data

Bédard, Matthieu F. ; Munoz-Javier, Almudena ; Müller, Renate ; del Pino, Pablo ; Fery, Andreas ; Parak, Wolfgang J. ; Skirtach, Andre G. ; Sukhorukov, Gleb B.:
On the mechanical stability of polymeric microcontainers functionalized with nanoparticles.
In: Soft Matter. Vol. 5 (2009) Issue 1 . - pp. 148-155.
ISSN 1744-6848
DOI: https://doi.org/10.1039/b812553h

Official URL: Volltext

Abstract in another language

We present key factors that influence the mechanical stability of polyelectrolyte/nanoparticle composite microcontainers and their encapsulation behavior by thermal shrinkage.Poly(diallyldimethylammonium chloride) (PDADMAC), poly(styrenesulfonate) (PSS) microshells and citrate-stabilized gold nanoparticles are used. The presence of nanoparticles in the microshell renders the encapsulation process by heat-shrinking more difficult. The encapsulation efficiency is found to decrease as the concentration of material to be encapsulated increases. Increasing nanoparticle content in the microshell or the concentration of dextran increases the likelihood of getting fused and damaged capsules during encapsulation. On the other hand, mechanical studies show that doping microshells with gold nanoparticles significantly increases their stiffness and resistance to deformation.Internalization of capsules by cells supports that the incorporation of metal nanoparticles makes the shells more resistant to deformation. This work provides information of significant interest for the potential biomedical applications of polymeric microshells such as intracellular storage and delivery.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 08 Dec 2014 09:47
Last Modified: 09 Feb 2015 14:07
URI: https://eref.uni-bayreuth.de/id/eprint/4003