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Total hemoglobin mass : A new parameter to detect blood doping?


Prommer, Nicole ; Sottas, Pierre-Edouard ; Schoch, Christian ; Schumacher, Yorck Olaf ; Schmidt, Walter:
Total hemoglobin mass : A new parameter to detect blood doping?
In: Medicine & Science in Sports & Exercise. Bd. 40 (2008) Heft 12 . - S. 2112-2118.
ISSN 1530-0315
DOI: https://doi.org/10.1249/MSS.0b013e3181820942


Purpose: All kinds of blood manipulations aim to increase the total hemoglobin mass (tHb-mass). To establish tHb-mass as an effective screening parameter for detecting blood doping, the knowledge of its normal variation over time is necessary. The aim of the present study, therefore, was to determine the intraindividual variance of tHb-mass in elite athletes during a training year emphasizing off, training, and race seasons at sea level. Methods: tHb-mass and hemoglobin concentration ([Hb]) were determined in 24 endurance athletes five times during a year and were compared with a control group (n = 6). An analysis of covariance was used to test the effects of training phases. age. gender, competition level, body mass, and training volume. Three error models. based on 1) a total percentage error of measurement, 2) the combination of a typical percentage error (TE) of analytical origin with an absolute SD of biological origin, and 3) between-subject and within-subject variance components as obtained by an analysis of variance, were tested. Results: In addition to the expected influence of performance status, the main results were that the effects of training volume (P = 0.20) and training phases (P = 0.81) on tHb-mass were not significant. We found that within-subject variations mainly have an analytical origin (TE similar to 1.4%) and a very small SD (7.5 g) of biological origin. Conclusion: tHb-mass shows very low individual oscillations during a training year (<6%), and these oscillations are below the expected changes in tHb-mass due to Herythropoetin (EPO) application or blood infusion (similar to 10%). The high stability of tHb-mass over a period of 1 year suggests that it should be included in an athlete's biological passport and analyzed by recently developed probabilistic inference techniques that define subject-based reference ranges

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Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Zusätzliche Informationen: ISI:000261164600014
Keywords: ABUSE; AGE; ALTERED ERYTHROPOIESIS; ANALYSIS; athlete; athletes; BAYESIAN DETECTION; BAYESIAN MODEL; biological passport; BIOMARKERS; blood; blood doping; blood manipulations; BLOOD PASS; blood transfusion; BODY; CO-REBREATHING METHOD; competition; COUNT; doping; elite athletes; endurance; EPO; EPO DOPING; hemoglobin; HEMOGLOBIN CONCENTRATION; hemoglobin mass; INFERENCE; infusion; INTRAINDIVIDUAL VARIANCE; MASS; method; methods; MODEL; PERFORMANCE; RANGES; RECOMBINANT-HUMAN-ERYTHROPOIETIN; SEA-LEVEL; SEASONS; Sport; SPORTS; STABILITY; T/E RATIO; Test; total hemoglobin; training; VALUES; VOLUME
Institutionen der Universität: Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie)
Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie) > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie) - Univ.-Prof. Dr. Walter Schmidt
Fakultäten > Kulturwissenschaftliche Fakultät
Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
Eingestellt am: 22 Nov 2017 08:42
Letzte Änderung: 23 Nov 2017 08:14
URI: https://eref.uni-bayreuth.de/id/eprint/40425