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Phenolic profile, chemical relationship and antifungal activity of Andean Hypericum species

Titelangaben

Tocci, Noemi ; Weil, Tobias ; Perenzoni, Daniele ; Narduzzi, Luca ; Madriñán, Santiago ; Crockett, Sarah ; Nürk, Nicolai M. ; Cavalieri, Duccio ; Mattivi, Fulvio:
Phenolic profile, chemical relationship and antifungal activity of Andean Hypericum species.
In: Industrial Crops and Products. Bd. 112 (Februar 2018) . - S. 32-37.
ISSN 1872-633X
DOI: https://doi.org/10.1016/j.indcrop.2017.10.030

Abstract

Fungal infections represent a major and increasing threat to public health resulting in a growing demand for new drugs. The genus Hypericum is a rich source of bioactive secondary metabolite, including antimicrobials and the exploration of uninvestigated species holds the potential for the discovery of novel molecules for the pharma- ceutical market. Here the chemical composition, phytochemical relationships and the antifungal potential of seven of neglected Andean Hypericum species has been investigated. Through liquid chromatography and mass spectrometry analysis, 34 phenolic compounds have been identified and quantified. Quercetin derivatives, ca- techin and epicatechin, procyanidin B2 and chlorogenic acid derivatives represented the most abundant com- pounds in all extracts. The antifungal activity was evaluated against a panel of clinical isolates of pathogenic fungi. Four of the tested extracts were active against C. albicans (MIC50 < 353.25 μg/ml) and five against C. parapsilosis (MIC50 < 1000 μg/ml). Noteworthy was the activity of H. garciae, that was subjected to a com- prehensive investigation against a broad panel of Candida spp. clinical strains. H. garciae extracts showed higher activity than fluconazole against C. intermedia and C. parapsilosis. The methanolic extract was active against all of the tested species with MIC50 values as low as 4 μl/ml and 5 μl/ml against C. lusitaniae and C. albicans respec- tively and 64 μl/ml against C. glabrata. The chloroformic extract displayed a higher activity than fluconazole against C. tropicalis. The presented data represent an advancement in the knowledge of the chemistry and antifungal potential of Hypericum species and offer interesting suggestions for deeper studies in the field of chemotaxonomy and drug discovery.

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Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Zusätzliche Informationen: BAYCEER143451
Institutionen der Universität: Forschungseinrichtungen
Forschungseinrichtungen > Forschungszentren
Forschungseinrichtungen > Forschungszentren > Bayreuther Zentrum für Ökologie und Umweltforschung - BayCEER
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Pflanzensystematik
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik
Eingestellt am: 02 Jan 2018 14:38
Letzte Änderung: 03 Jan 2018 06:57
URI: https://eref.uni-bayreuth.de/id/eprint/41097