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Recombinant spider silk-based bioinks

Title data

DeSimone, Elise ; Schacht, Kristin ; Pellert, Alexandra ; Scheibel, Thomas:
Recombinant spider silk-based bioinks.
In: Biofabrication. Vol. 9 (2017) Issue 4 . - 14 S..
ISSN 1758-5090
DOI: https://doi.org/10.1088/1758-5090/aa90db

Abstract in another language

Bioinks, 3D cell culture systems which can be printed, are still in the early development stages. Currently, extensive research is going into designing printers to be more accommodating to bioinks, designing scaffolds with stiff materials as support structures for the often soft bioinks, and modifying the bioinks themselves. Recombinant spider silk proteins, a potential biomaterial component for bioinks, have high biocompatibility, can be processed into several morphologies and can be modified with cell adhesion motifs to enhance their bioactivity. In this work, thermally gelled hydrogels made from recombinant spider silk protein encapsulating mouse fibroblast cell line BALB/3T3 were
prepared and characterized. The bioinks were evaluated for performance in vitro both before and after printing, and it was observed that unprinted bioinks provided a good platform for cell spreading and proliferation, while proliferation in printed scaffolds was prohibited. To improve the properties of the printed hydrogels, gelatin was given as an additive and thereby served indirectly as a plasticizer, improving the resolution of printed strands. Taken together, ecombinant spider silk proteins and hydrogels made thereof show good potential as a bioink, warranting further evelopment.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: spider silk; engineered protein; recombinant protein; self-assembly; hydrogel; dispense plotting
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 05 Jan 2018 07:49
Last Modified: 05 Jan 2018 07:49
URI: https://eref.uni-bayreuth.de/id/eprint/41543