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Engineered Collagen : A Redox Switchable Framework for Tunable Assembly and Fabrication of Biocompatible Surfaces

Title data

Golser, Adrian V. ; Röber, Matthias ; Börner, Hans G. ; Scheibel, Thomas:
Engineered Collagen : A Redox Switchable Framework for Tunable Assembly and Fabrication of Biocompatible Surfaces.
In: ACS Biomaterials Science & Engineering. Vol. 4 (2018) Issue 6 . - pp. 2106-2114.
ISSN 2373-9878
DOI: https://doi.org/10.1021/acsbiomaterials.7b00583

Abstract in another language

Collagen, processed into several morphologies and riginating from various sources, has long since been used as a biocompatible material that can assist wound healing and tissue regeneration. With the advent of biotechnology and solid-phase peptide synthesis, new possibilities arise to create rationally designed biomaterials based on collagen sequences incorporating new functionalities while maintaining the beneficial properties of natural collagen. In this study a new class of synthetic collagen materials is presented,defined by its simplistic core structure and its therefore predictable behavior. These so-called eCols (engineered collagens) consist of a varying number of Gly-Pro-Pro repeats, a redox-switchable aminoterminal nucleation site and an optional carboxyterminal cell adhesion motif. We show which of these proteins are able to self-assemble into triple helices and cross-linked gelatinous networks and provide insights into their cytocompatibility in vitro.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: collagen folding; synthetic peptides; cell adhesion; biopolymer self-assembly
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 05 Jul 2018 13:37
Last Modified: 05 Jul 2018 13:37
URI: https://eref.uni-bayreuth.de/id/eprint/44976