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Phagosomal transport depends strongly on phagosome size

Title data

Keller, Steve ; Berghoff, Konrad ; Kress, Holger:
Phagosomal transport depends strongly on phagosome size.
In: Scientific Reports. Vol. 7 (6 December 2017) Issue 1 . - 17068.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-017-17183-7

Official URL: Volltext

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Abstract in another language

Macrophages internalize pathogens for intracellular degradation. An important part of this process is the phagosomal transport from the cell periphery to the perinuclear region. Biochemical factors are known to influence the fate of phagosomes. Here, we show that the size of phagosomes also has a strong influence on their transport. We found that large phagosomes are transported persistently to the nucleus, whereas small phagosomes show strong bidirectional transport. We show that dynein motors play a larger role in the transport of large phagosomes, whereas actin filament-based motility plays a larger role in the transport of small phagosomes. Furthermore, we investigated the spatial distribution of dyneins and microtubules around phagosomes and hypothesize that dynein and microtubule density differences between the nucleus-facing side of phagosomes and the opposite side could explain part of the observed transport characteristics. Our findings suggest that a size-dependent cellular sorting mechanism might exist that supports macrophages in their immunological roles.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Professor Experimental Physics VI - Biologial Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Professor Experimental Physics VI - Biologial Physics > Professor Experimental Physics VI - Biologial Physics - Univ.-Prof. Dr. Holger Kreß
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Nonlinear Dynamics
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Profile Fields
Profile Fields > Advanced Fields
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 530 Physics
500 Science > 570 Life sciences, biology
Date Deposited: 25 Aug 2018 21:00
Last Modified: 15 Jul 2021 05:26
URI: https://eref.uni-bayreuth.de/id/eprint/45582