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Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues

Title data

Roshanbinfar, Kaveh ; Vogt, Lena ; Greber, Boris ; Diecke, Sebastian ; Boccaccini, Aldo R. ; Engel, Felix B. ; Scheibel, Thomas:
Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues.
In: Advanced Functional Materials. (2018) . - pp. 1-10. - No. 1803951.
ISSN 1616-301X
DOI: https://doi.org/10.1002/adfm.201803951

Abstract in another language

Cardiac tissue engineering is a promising strategy to treat heart failure. Yet,
several issues remain to be resolved including the prevention of arrhythmia
caused by inefficient electrical coupling within the graft and between
graft and host tissue. Here, a biohybrid hydrogel composed of collagen,
alginate, and electroconductive poly(3,4-ethylenedioxythiophene):polysty
rene sulfonate (PEDOT:PSS) is developed that exhibits extracellular matrix–
mimetic fibrous structures and enhanced electrical coupling as well and
cardiomyocyte maturation. Presence of PEDOT:PSS in the hydrogel improves
electrical conductivity and prevents arrhythmia of tissue constructs
containing neonatal rat cardiomyocytes. Moreover, it results in increasing
beating frequencies reaching more than 200 beats min−1 endogenous
frequencies. In addition, cardiomyocytes exhibit increased alignment
and density in these constructs, improved sarcomere organization, and
enhanced connexin 43 expression, suggesting maturation of the cardiac
tissue. Importantly, the here developed electroconductive biohybrid
hydrogels also improve maturation and beating properties of humaninduced
pluripotent stem cell–derived cardiomyocytes. These cells exhibit
1.9 μm near adult sarcomeric length, enhanced beating frequency, increased
speed of contraction, and larger contraction amplitude. Collectively, the data
demonstrate the potential of this electroconductive biohybrid hydrogel to
improve tissue engineering approaches to treat heart failure and possibly
diseases of other electrically sensitive tissues.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: electroconductive hydrogels; heart; hiPSC; maturation; tissue engineering
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 25 Sep 2018 06:11
Last Modified: 25 Sep 2018 06:11
URI: https://eref.uni-bayreuth.de/id/eprint/45878