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Heterocycle biosynthesis via C-H functionalization

Title data

Hahn, Frank:
Heterocycle biosynthesis via C-H functionalization.
In: Nature Catalysis. Vol. 1 (12 December 2018) . - p. 905.
ISSN 2520-1158
DOI: https://doi.org/10.1038/s41929-018-0194-2

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

The biosynthesis of the pharmacophoric tetrahydropyran of the clinically important antibiotic mupirocin remained enigmatic for a long time. Now, research shows that this ring is formed by a unique epoxidation–epoxide-opening cascade starting from a non-activated alkane.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Antibiotics; Biosynthesis; Oxidoreductases
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professur Organische Chemie - Lebensmittelchemie
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professur Organische Chemie - Lebensmittelchemie > Professur Organische Chemie - Lebensmittelchemie - Univ.-Prof. Dr. Frank Hahn
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 10 Jan 2019 09:56
Last Modified: 10 Jan 2019 09:56
URI: https://eref.uni-bayreuth.de/id/eprint/46869