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The Tat protein of equine infectious anemia virus (EIAV) activates cellular gene expression by read-through transcription

Title data

Rosin-Arbesfeld, Rina ; Willbold, Dieter ; Yaniv, Abraham ; Gazit, Arnona:
The Tat protein of equine infectious anemia virus (EIAV) activates cellular gene expression by read-through transcription.
In: Gene. Vol. 219 (September 1998) Issue 1-2 . - pp. 25-35.
ISSN 1879-0038
DOI: https://doi.org/10.1016/S0378-1119(98)00389-8

Abstract in another language

The Tat protein of equine infectious anemia virus, EIAV, was shown to augment viral gene expression, presumably through interaction with the Tat responsive element, TAR. Recently, cell-free polyadenylation assays suggested that perturbation of the EIAV TAR secondary structure diminished polyadenylation efficiency. The present study indicates that the EIAV TAR regulates the efficiency of the 3′-end processing of viral RNA also in transfected cells. Moreover, our data suggest that the provision of the EIAV Tat protein in trans potentiates read-through transcription through the 3′ viral long terminal repeat (3′ LTR), thus suggesting activation of downstream-located cellular genes.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 23 Jan 2019 10:11
Last Modified: 16 May 2019 05:37
URI: https://eref.uni-bayreuth.de/id/eprint/46998