Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

hK5 and hK7, two Serine Proteinases Abundant in Human Skin, are Inhibited by LEKTI Domain 6

Title data

Egelrud, T. ; Brattsand, M. ; Kreutzmann, P. ; Walden, M. ; Vitzithum, Klaus ; Marx, Ute C. ; Forssmann, Wolf-Georg ; Mägert, H. J.:
hK5 and hK7, two Serine Proteinases Abundant in Human Skin, are Inhibited by LEKTI Domain 6.
In: British Journal of Dermatology. Vol. 153 (December 2005) Issue 6 . - pp. 1200-1203.
ISSN 1365-2133
DOI: https://doi.org/10.1111/j.1365-2133.2005.06834.x

Abstract in another language

BACKGROUND:
Several skin diseases and atopic disorders including Netherton syndrome and atopic dermatitis have been associated with mutations and deviations of expression of SPINK5, the gene encoding the human 15-domain serine proteinase inhibitor LEKTI. The biochemical mechanisms underlying this phenomenon have not yet been fully clarified.

OBJECTIVES:
To identify target proteinases of LEKTI important for processes of desquamation and inflammation of the skin which will enable the development of specific drugs.

METHODS:
The inhibitory activities of LEKTI domains 6 and 15 were tested on a number of commercially available serine proteinases and also on the purified kallikreins hK5 and hK7. In addition, recombinant hK5 was used.

RESULTS:
LEKTI domain 6 is a potent inhibitor of hK5 and hK7, whereas LEKTI domain 15 exhibits inhibitory activity on plasmin. hK5 and hK7 in particular are relevant to skin disorders.

CONCLUSIONS:
The inhibition of hK5 and hK7 by LEKTI domain 6 indicates an important regulatory role of LEKTI in processes of skin desquamation and inflammation, which may explain the severe pathological symptoms associated with abnormalities of SPINK5 and/or its expression. Thus, LEKTI represents a potential drug for the treatment of these disorders.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 28 Jan 2019 13:08
Last Modified: 16 May 2019 05:37
URI: https://eref.uni-bayreuth.de/id/eprint/47066