Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Long-term potentiation in an innexin-based electrical synapse

Title data

Welzel, Georg ; Schuster, Stefan:
Long-term potentiation in an innexin-based electrical synapse.
In: Scientific Reports. Vol. 2018 (22 August 2018) Issue 8 . - No. 12579.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-30966-w

Related URLs

Project information

Project title:
Project's official titleProject's id
Open Access PublizierenNo information

Abstract in another language

Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However, it remains unclear if this similarity extends also to more sophisticated functions such as long-term potentiation which is only known in connexin-based synapses. Here we show that this capacity is not unique to connexin-based synapses. Using a method that allowed us to quantitatively measure gap-junction conductance we provide the first and unequivocal evidence of long-term potentiation in an innexin-based electrical synapse. Our findings suggest that long-term potentiation is a property that has likely existed already in ancestral gap junctions. They therefore could provide a highly potent system to dissect shared molecular mechanisms of electrical synapse plasticity.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Electrical synapses; long-term potentiation
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster
Result of work at the UBT: Yes
DDC Subjects: 500 Science
Date Deposited: 27 Feb 2019 13:09
Last Modified: 27 Feb 2019 13:27
URI: https://eref.uni-bayreuth.de/id/eprint/47657