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Structure of Amyloid A4-(1-40)-Peptide of Alzheimer's Disease

Title data

Sticht, Heinrich ; Bayer, Peter ; Willbold, Dieter ; Dames, Sonja ; Hilbich, Caroline ; Beyreuther, Konrad ; Frank, Rainer W. ; Rösch, Paul:
Structure of Amyloid A4-(1-40)-Peptide of Alzheimer's Disease.
In: European Journal of Biochemistry. Vol. 233 (1 October 1995) Issue 1 . - pp. 293-298.
ISSN 1432-1033

Official URL: Volltext

Abstract in another language

One of the principal peptide components of the amyloid plaque deposits of Alzheimer's disease in humans is the 40-amino-acid peptide 8-amyloid A4-(1-40)-peptide. The full-length A4-(I-40)-peptide was chemically synthesized and the sulution structure determined by two-dimensional nuclear magnetic resonance spectroscopy and restrained molecular-dynamics calculations. Synthetic human A4-(1-40)-peptide was soluble and non-aggregating for several days in 40% (by vol.) trifluoroethanol/water. All spin systems could ...

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 19 Dec 2014 09:38
Last Modified: 08 Dec 2015 06:45
URI: https://eref.uni-bayreuth.de/id/eprint/5082