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The Influence of the Chain Length of Polycations on their Complexation with Anionic Liposomes

Title data

Ivashkov, Oleg V. ; Sybachin, Andrey V. ; Efimova, Anna A. ; Pergushov, Dmitry V. ; Orlov, Viktor N. ; Schmalz, Holger ; Yaroslavov, Alexander A.:
The Influence of the Chain Length of Polycations on their Complexation with Anionic Liposomes.
In: ChemPhysChem. Vol. 16 (2015) Issue 13 . - pp. 2849-2853.
ISSN 1439-4235
DOI: https://doi.org/10.1002/cphc.201500474

Project information

Project financing: Russian Science Foundation
Russian Foundation for Basic Research

Abstract in another language

A series of strong polycations is synthesized through the anionic polymerization of 2‐vinylpyridine, followed by subsequent quaternization of the resulting polymer. Polycations based on quaternized 2‐vinylpyridine (PVPQs) with degrees of polymerization (DP) from 20 to 440 are adsorbed on the surface of small anionic liposomes. Liposome/PVPQ complexes are characterized by using a number of physicochemical methods. All PVPQs are totally adsorbed onto the liposome surface up to a certain concentration at which saturation is reached (which is specific for each PVPQ). The integrity of the adsorbed liposomes remains intact. Short PVPQs interact with anionic lipids localized on the outer membrane leaflet, whereas long PVPQs extract anionic lipids from the inner to outer leaflet. Complexes tend to aggregate, and the largest aggregates are formed when the initial charge of the liposomes is fully neutralized by the charge of the PVPQ. PVPQs with intermediate DPs demonstrate behavioral features of both short and long PVPQs. These results are important for the interpretation of the biological effects of cationic polymers and the selection of cationic polymers for biomedical applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 12 Dec 2019 08:24
Last Modified: 12 Dec 2019 08:24
URI: https://eref.uni-bayreuth.de/id/eprint/53563