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Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications

Title data

Kumari, Sushma ; Bargel, Hendrik ; Scheibel, Thomas:
Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications.
In: Macromolecular Rapid Communications. Vol. 41 (January 2020) Issue 1 . - p. 1900426. - 6 S..
ISSN 1521-3927
DOI: https://doi.org/10.1002/marc.201900426

Abstract in another language

Fabricating biomaterials with antimicrobial activity to prevent the growth of detrimental microorganisms is of great scientific and practical interest. Here, composite materials comprising recombinant spider silk proteins and mesoporous silica nanoparticles (MSN) loaded with selected antibiotics and antimycotics are fabricated into films and hydrogels. The derived composite materials exhibit excellent antimicrobial properties with sustained release of antibiotics over the course of 15 days. Furthermore, antibiotics/antimycotics inclusion does not impair the cytocompatibility of the composite materials, all of which promote fibroblast cell adhesion and proliferation. Finally, processing of spider silk–MSN composite hydrogels using 3D printing is shown to enable the fabrication of patient‐specific antimicrobial implants to prevent infection in the near future.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: Special Issue: 100 Years of Macromolecular Chemistry.
This article also appears in:
Hot Topic: Mesoporous Materials
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 20 Jan 2020 12:19
Last Modified: 20 Jan 2020 12:19
URI: https://eref.uni-bayreuth.de/id/eprint/54158