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Humenik, Martin ; Pawar, Kiran ; Scheibel, Thomas:
Nanostructured, Self-Assembled Spider Silk Materials for Biomedical Applications.
In: Perrett, Sarah ; Buell, Alexander K. ; Knowles, Thomas P. J.
(Hrsg.):
Biological and Bio-inspired Nanomaterials : Properties and Assembly Mechanisms. -
Singapore
,
2019
. - S. 187-221
. - (Advances in Experimental Medicine and Biology
; 1174
)
ISBN 978-981-139-791-2
DOI: https://doi.org/10.1007/978-981-13-9791-2_6
Abstract
The extraordinary mechanical properties of spider silk fibers result from the interplay of composition, structure and self-assembly of spider silk proteins (spidroins). Genetic approaches enabled the biotechnological production of recombinant spidroins which have been employed to unravel the self-assembly and spinning process. Various processing conditions allowed to explore non-natural morphologies including nanofibrils, particles, capsules, hydrogels, films or foams. Recombinant spider silk proteins and materials made thereof can be utilized for biomedical applications, such as drug delivery, tissue engineering or 3D-biomanufacturing.