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Comparative study and simulation of tumor cell inactivation by microwave and conventional heating

Title data

Rosin, Andreas ; Hader, Michael ; Drescher, Corinna ; Suntinger, Magdalena ; Gerdes, Thorsten ; Willert-Porada, Monika ; Gaipl, Udo S. ; Frey, Benjamin:
Comparative study and simulation of tumor cell inactivation by microwave and conventional heating.
In: COMPEL : The International Journal for Computation and Mathematics in Electrical and Electronic Engineering. Vol. 37 (18 November 2018) Issue 6 . - pp. 1893-1904.
ISSN 0332-1649
DOI: https://doi.org/10.1108/COMPEL-03-2017-0144

Abstract in another language

Purpose – This paper aims to investigate in a self-designed closed loop reactor process conditions for thermal inactivation of B16 melanoma cells by microwave and conventional heating.

Design/methodology/approach – Besides control experiments (37°C), inactivation rate was determined in the range from 42°C to 46°C. Heating was achieved either by microwave radiation at 2.45 GHz or by warm water. To distinguish viable from dead cells, AnnexinV staining method was used and supported by field effect scanning electron microscopy (FE-SEM) imaging. Furthermore, numerical simulations were done to get a closer look into both heating devices. To investigate the thermal influence on cell inactivation and the differences between heating methods, a reaction kinetics approach was added as well.

Findings – Control experiments and heating at 42°C resulted in low inactivation rates. Inactivation rate at 44°C remained below 12% under conventional, whereas it increased to >70% under microwave heating. At 46°C, inactivation rate attained 68% under conventional heating; meanwhile, even 88% were determined under microwave heating. FE-SEM images showed a porous membrane structure under microwave heating in contrast to mostly intact conventional heated cells. Numerical simulations of both heating devices and a macroscopic Arrhenius approach could not sufficiently explain the observed differences in inactivation.

Originality/value – A combination of thermal and electrical effects owing to microwave heating results in higher inactivation rates than conventional heating achieves. Nevertheless, it was not possible to determine the exact mechanisms of inactivation under microwave radiation.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Microwave heating; Multiphysics simulation; Tumour cell inactivation
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Ceramic Materials > Chair Ceramic Materials - Univ.-Prof. Dr.-Ing. Walter Krenkel
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 10 Feb 2020 09:46
Last Modified: 10 Feb 2020 09:46
URI: https://eref.uni-bayreuth.de/id/eprint/54305