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Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons

Title data

Hassan, Amira ; Rodriguez, Pablo Araguas ; Heidmann, Stefan ; Walmsley, Emma L. ; Aughey, Gabriel N. ; Southall, Tony D.:
Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons.
In: eLIFE. Vol. 9 (7 April 2020) .
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.55159

Abstract in another language

Condensin complexes are essential for mitotic chromosome assembly and segregation during cell divisions, however, little is known about their functions in post-mitotic cells. Here we report a role for the condensin I subunit Cap-G in Drosophila neurons. We show that, despite not requiring condensin for mitotic chromosome compaction, post-mitotic neurons express Cap-G. Knockdown of Cap-G specifically in neurons (from their birth onwards) results in developmental arrest, behavioural defects, and dramatic gene expression changes, including reduced expression of a subset of neuronal genes and aberrant expression of genes that are not normally expressed in the developing brain. Knockdown of Cap-G in mature neurons results in similar phenotypes but to a lesser degree. Furthermore, we see dynamic binding of Cap-G at distinct loci in progenitor cells and differentiated neurons. Therefore, Cap-G is essential for proper gene expression in neurons and plays an important role during the early stages of neuronal development.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Result of work at the UBT: No
DDC Subjects: 500 Science
500 Science > 570 Life sciences, biology
Date Deposited: 22 Apr 2020 06:10
Last Modified: 22 Apr 2020 06:10
URI: https://eref.uni-bayreuth.de/id/eprint/54988