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Target grafting of poly(2-(dimethylamino)ethyl methacrylate) to biodegradable block copolymers

Title data

Diaz, Ivonne L. ; Sierra, Cesar A. ; Jérôme, Valérie ; Freitag, Ruth ; Perez, León D.:
Target grafting of poly(2-(dimethylamino)ethyl methacrylate) to biodegradable block copolymers.
In: Journal of Polymer Science. Vol. 58 (2020) Issue 16 . - pp. 2168-2180.
ISSN 2642-4169
DOI: https://doi.org/10.1002/pol.20200204

Abstract in another language

A series of copolymers composed of methoxy poly(ethylene glycol) and a hydrophobic block of poly(ɛ-caprolactone-co-propargyl carbonate) grafted with poly(2-[dimethylamino]ethyl methacrylate) was synthesized by combining ring opening polymerization, azide-alkyne click reaction, and atom transfer radical polymerization (ATRP). Well-defined copolymers with a target composition and a tailored structure were achieved via the grafting from approach by using a single catalytic system for both click reaction and ATRP. Kinetic studies demonstrated the controlled/living character of the employed polymerization methods. The thermal properties and self-assembly in aqueous medium of the graft copolymers were dependent on their composition. The resulting polymeric materials showed low cytotoxicity toward L929 cells, demonstrating their potential for biomedical applications. This type of materials containing cationic side chains tethered to biocompatible and biodegradable segments could be the basis for promising candidates as drug and gene delivery systems.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 02 Sep 2020 06:06
Last Modified: 02 Sep 2020 06:06
URI: https://eref.uni-bayreuth.de/id/eprint/56714