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Sirt4 : A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer

Title data

Tomaselli, Daniela ; Steegborn, Clemens ; Mai, Antonello ; Rotili, Dante:
Sirt4 : A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer.
In: Frontiers in Oncology. Vol. 10 (April 2020) . - No. 474.
ISSN 2234-943X
DOI: https://doi.org/10.3389/fonc.2020.00474

Abstract in another language

Sirtuins are NAD+-dependent deacylases that play crucial roles in the regulation of cellular metabolism, and as a result, are implicated in several diseases. The mitochondrial sirtuin Sirt4, for a long time considered as mainly a mono-ADP-ribosyltransferase, recently has shown a robust deacylase activity in addition to the already accepted substrate-dependent lipoamidase and deacetylase properties. Through these and likely other enzymatic and non-enzymatic activities, Sirt4 closely controls various metabolic events, and its dysregulation is linked to various aging-related disorders, including type 2 diabetes, cardiac hypertrophy, non-alcoholic fatty liver disease, obesity, and cancer. For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a context-dependent manner. In addition to what is already known about the roles of Sirt4 in different biological settings, further studies are certainly still needed in order to validate this enzyme as a new potential target for various aging diseases.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Cancer; Metabolism; Mitochondria; Protein deacylation; Sirtuins
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 07 Sep 2020 08:10
Last Modified: 07 Sep 2020 08:10
URI: https://eref.uni-bayreuth.de/id/eprint/56817