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Environmental exposure enhances the internalization of microplastic particles into cells

Title data

Ramsperger, Anja ; Narayana, Vinay Kumar Bangalore ; Gross, Wolfgang ; Mohanraj, John ; Thelakkat, Mukundan ; Greiner, Andreas ; Schmalz, Holger ; Kress, Holger ; Laforsch, Christian:
Environmental exposure enhances the internalization of microplastic particles into cells.
In: Science Advances. Vol. 6 (9 December 2020) Issue 50 . - pp. 1-9. - eabd1211.
ISSN 2375-2548
DOI: https://doi.org/10.1126/sciadv.abd1211

Project information

Project title:
Project's official titleProject's id
SFB 1357 MikroplastikSFB1357
DFG INST 91/289-1 FUGGDFG

Project financing: Deutsche Forschungsgemeinschaft
Studienstiftung des deutschen Volkes
Elite-Netzwerk Bayern

Abstract in another language

Microplastic particles ubiquitously found in the environment are ingested by a huge variety of organisms. Subsequently, microplastic particles can translocate from the gastrointestinal tract into the tissues likely by cellular internalization. The reason for cellular internalization is unknown, since this has only been shown for specifically surface-functionalized particles. We show that environmentally exposed microplastic particles were internalized significantly more often than pristine microplastic particles into macrophages. We identified biomolecules forming an eco-corona on the surface of microplastic particles, suggesting that environmental exposure promotes the cellular internalization of microplastics. Our findings further indicate that cellular internalization is a key route by which microplastic particles translocate into tissues, where they may cause toxicological effects that have implications for the environment and human health.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: H. Kress and C. Laforsch are joint senior authors
Keywords: microplastics; environment; environmental exposure; eco-corona; cell internalization
Institutions of the University: Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Professor Experimental Physics VI - Biologial Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Professor Experimental Physics VI - Biologial Physics > Professor Experimental Physics VI - Biologial Physics - Univ.-Prof. Dr. Holger Kreß
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Ecology I
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Ecology I > Chair Animal Ecology I - Univ.-Prof. Dr. Christian Laforsch
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Ecology and the Environmental Sciences
Profile Fields > Advanced Fields > Molecular Biosciences
Research Institutions
Research Institutions > Collaborative Research Centers, Research Unit
Research Institutions > Collaborative Research Centers, Research Unit > SFB 1357 - MIKROPLASTIK
Graduate Schools
Graduate Schools > University of Bayreuth Graduate School
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 11 Dec 2020 09:42
Last Modified: 12 Oct 2021 11:40
URI: https://eref.uni-bayreuth.de/id/eprint/61000