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A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels

Title data

Nahm, Daniel ; Weigl, Franziska ; Schaefer, Natascha ; Sancho, Ana ; Frank, Andreas ; Groll, Jürgen ; Villmann, Carmen ; Schmidt, Hans-Werner ; Dalton, Paul D. ; Luxenhofer, Robert:
A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels.
In: Materials Horizons. Vol. 7 (2020) Issue 3 . - pp. 928-933.
ISSN 2051-6355
DOI: https://doi.org/10.1039/C9MH01654F

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

In this study, we designed a novel biomaterial ink platform based on hydrophilic poly(2-ethyl-2-oxazine) (PEtOzi) specifically for melt electrowriting (MEW). This material crosslinks spontaneously after processing via dynamic Diels–Alder click chemistry. These direct-written microperiodic structures rapidly swell in water to yield thermoreversible hydrogels. These hydrogels are robust enough for repeated aspiration and ejection through a cannula without structural damage, despite their high water content of 84. Moreover, the scaffolds retain functional groups for modification using click chemistry and therefore can be readily functionalized as demonstrated using fluorophores and peptides to facilitate visualization and cell attachment. The PEtOzi hydrogel developed here is compatible with confocal imaging and staining protocols for cells. In summary, an advanced material platform based on PEtOzi is reported that is compatible with MEW and results in functionalizable chemically crosslinked microperiodic hydrogels.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I > Chair Macromolecular Chemistry I - Univ.-Prof. Dr. Hans-Werner Schmidt
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Research Institutions
Research Institutions > Affiliated Institutes
Research Institutions > Affiliated Institutes > Bavarian Polymer Institute (BPI)
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 540 Chemistry
Date Deposited: 11 Dec 2020 10:06
Last Modified: 11 Dec 2020 10:06
URI: https://eref.uni-bayreuth.de/id/eprint/61009