Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar


Evolution, folding, and design of TIM barrels and related proteins

Title data

Romero-Romero, Sergio ; Kordes, Sina ; Michel, Florian ; Höcker, Birte:
Evolution, folding, and design of TIM barrels and related proteins.
In: Current Opinion in Structural Biology. Vol. 68 (June 2021) . - pp. 94-104.
ISSN 0959-440X
DOI: https://doi.org/10.1016/j.sbi.2020.12.007

Project information

Project title:
Project's official titleProject's id
ERC Consolidator Grant "Protein Lego"647548
Volkswagenstiftung Grant94747
Humboldt-Bayer Research Fellowship for Postdoctoral ResearchersNo information

Project financing: VolkswagenStiftung

Abstract in another language

Proteins are chief actors in life that perform a myriad of exquisite functions. This diversity has been enabled through the evolution and diversification of protein folds. Analysis of sequences and structures strongly suggest that numerous protein pieces have been reused as building blocks and propagated to many modern folds. This information can be traced to understand how the protein world has diversified. In this review, we discuss the latest advances in the analysis of protein evolutionary units, and we use as a model system one of the most abundant and versatile topologies, the TIM-barrel fold, to highlight the existing common principles that interconnect protein evolution, structure, folding, function, and design.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Birte Höcker
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 570 Life sciences, biology
Date Deposited: 26 Jan 2021 07:47
Last Modified: 26 Jan 2021 08:06
URI: https://eref.uni-bayreuth.de/id/eprint/62397