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Induction of axonal outgrowth in mouse hippocampal neurons via bacterial magnetosomes

Title data

De Vincentiis, Sara ; Falconieri, Alessandro ; Mickoleit, Frank ; Cappello, Valentina ; Schüler, Dirk ; Raffa, Vittoria:
Induction of axonal outgrowth in mouse hippocampal neurons via bacterial magnetosomes.
In: International Journal of Molecular Sciences. Vol. 22 (16 April 2021) Issue 8 . - Art.Nr. 4126.
ISSN 1422-0067
DOI: https://doi.org/10.3390/ijms22084126

Project information

Project title:
Project's official titleProject's id
MagBioFabNo information

Project financing: Bundesministerium für Bildung und Forschung

Abstract in another language

Magnetosomes are membrane-enclosed iron oxide crystals biosynthesized by magnetotactic bacteria. As the biomineralization of bacterial magnetosomes can be genetically controlled, they have become promising nanomaterials for bionanotechnological applications. In the present paper, we explore a novel application of magnetosomes as nanotool for manipulating axonal outgrowth via stretch-growth (SG). SG refers to the process of stimulation of axonal outgrowth through the application of mechanical forces. Thanks to their superior magnetic properties, magnetosomes have been used to magnetize mouse hippocampal neurons in order to stretch axons under the application of magnetic fields. We found that magnetosomes are avidly internalized by cells. They adhere to the cell membrane, are quickly internalized, and slowly degrade after a few days from the internalization process. Our data show that bacterial magnetosomes are more efficient than synthetic iron oxide nanoparticles in stimulating axonal outgrowth via SG.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: stretch-growth; magnetosomes; axonal elongation
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology > Chair Microbiology - Univ.-Prof. Dr. Dirk Schüler
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 19 Apr 2021 11:38
Last Modified: 19 Apr 2021 11:38
URI: https://eref.uni-bayreuth.de/id/eprint/64807