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High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish

Title data

Hecker, Alexander ; Anger, Pamela ; Braaker, Philipp N. ; Schulze, Wolfram ; Schuster, Stefan:
High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish.
In: Communications Biology. Vol. 3 (2020) Issue 1 . - No. 307.
ISSN 2399-3642
DOI: https://doi.org/10.1038/s42003-020-1034-x

Official URL: Volltext

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Open Access PublizierenNo information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

In non-mammalian vertebrates, some neurons can regenerate after spinal cord injury. One of these, the giant Mauthner (M-) neuron shows a uniquely direct link to a robust survival-critical escape behavior but appears to regenerate poorly. Here we use two-photon microscopy in parallel with behavioral assays in zebrafish to show that the M-axon can regenerate very rapidly and that the recovery of functionality lags by just days. However, we also find that the site of the injury is critical: While regeneration is poor both close and far from the soma, rapid regeneration and recovery of function occurs for injuries between 10% and 50% of total axon length. Our findings show that rapid regeneration and the recovery of function can be studied at remarkable temporal resolution after targeted injury of one single M-axon and that the decision between poor and rapid regeneration can be studied in this one axon.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Regeneration and repair in the nervous system; Spinal cord injury
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 590 Animals (Zoology)
Date Deposited: 22 May 2021 21:00
Last Modified: 25 May 2021 11:51
URI: https://eref.uni-bayreuth.de/id/eprint/65323