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Silk-Based Materials for Hard Tissue Engineering

Title data

Neubauer, Vanessa J. ; Döbl, Annika ; Scheibel, Thomas:
Silk-Based Materials for Hard Tissue Engineering.
In: Materials. Vol. 14 (1 February 2021) Issue 3 .
ISSN 1996-1944
DOI: https://doi.org/10.3390/ma14030674

Abstract in another language

Hard tissues, e.g., bone, are mechanically stiff and, most typically, mineralized. To design scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues must align with those found in the natural tissue.Combiningthese aspects poses challenges for material and construct design. Silk-based materials are promising for bone tissue regeneration as they fulfill several of such necessary requirements, and they are non-toxic and biodegradable. They can be processed into a variety of morphologies such as hydrogels, particles and fibers and can be mineralized. Therefore, silk-based materials are versatile candidates for biomedical applications in the field of hard tissue engineering. This review summarizes silk-based approaches for mineralized tissue replacements, and how to find the balance between sufficient material stiffness upon mineralization and cell survival upon attachment as well as nutrient supply.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: silk fibroin; silk spidroin; biomineralization; composite materials; bone; teeth; cartilage; tendon
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 13 Jul 2021 10:59
Last Modified: 13 Jul 2021 10:59
URI: https://eref.uni-bayreuth.de/id/eprint/66525