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Soft Elastic Fibrous Scaffolds for Muscle Tissue Engineering by Touch Spinning

Title data

Uribe-Gómez, Juan ; Posada-Murcia, Andrés ; Shukla, Amit ; Alkhamis, Hanin ; Salehi, Sahar ; Ionov, Leonid:
Soft Elastic Fibrous Scaffolds for Muscle Tissue Engineering by Touch Spinning.
In: ACS Applied Bio Materials. Vol. 4 (25 June 2021) Issue 7 . - pp. 5585-5597.
ISSN 2576-6422
DOI: https://doi.org/10.1021/acsabm.1c00403

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

This paper reports an approach for the fabrication of highly aligned soft elastic fibrous scaffolds using touch spinning of thermoplastic polycaprolactone–polyurethane elastomers and demonstrates their potential for the engineering of muscle tissue. A family of polyester–polyurethane soft copolymers based on polycaprolactone with different molecular weights and three different chain extenders such as 1,4-butanediol and polyethylene glycols with different molecular weight was synthesized. By varying the molar ratio and molecular weights between the segments of the copolymer, different physicochemical and mechanical properties were obtained. The polymers possess elastic modulus in the range of a few megapascals and good reversibility of deformation after stretching. The combination of the selected materials and fabrication methods allows several essential advantages such as biocompatibility, biodegradability, suitable mechanical properties (elasticity and softness of the fibers), high recovery ratio, and high resilience mimicking properties of the extracellular matrix of muscle tissue. Myoblasts demonstrate high viability in contact with aligned fibrous scaffolds, where they align along the fibers, allowing efficient cell patterning on top of the structures. Altogether, the importance of this approach is the fabrication of highly oriented fiber constructs that can support the proliferation and alignment of muscle cells for muscle tissue engineering applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Touch-spinning; biofabrication; skeletal muscle; polyurethane copolymers; microfibers
Institutions of the University: Faculties > Faculty of Engineering Science > Professor Biofabrication
Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering
URN: urn:nbn:de:bvb:703-epub-5725-3
Date Deposited: 20 Aug 2021 10:24
Last Modified: 20 Aug 2021 10:36
URI: https://eref.uni-bayreuth.de/id/eprint/66823