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Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch‐Spun Poly(Ester‐Urethane) Elastomer

Title data

Uribe Gómez, Juan Manuel ; Schönfeld, Dennis ; Posada Murcia, Andrés ; Roland, Michel-Manuel ; Caspari, Anja ; Synytska, Alla ; Salehi, Sahar ; Pretsch, Thorsten ; Ionov, Leonid:
Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch‐Spun Poly(Ester‐Urethane) Elastomer.
In: Macromolecular Bioscience. Vol. 22 (10 January 2022) Issue 4 . - No. 2100427.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202100427

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft
DFG IO 68/14-1
DFG IO 68/17-1
DFG SA 3575/1-1

Abstract in another language

Development of fiber-spinning technologies and materials with proper mechanical properties is highly important for the manufacturing of aligned fibrous scaffolds mimicking structure of the muscle tissues. Here, the authors report touch spinning of a thermoplastic poly(1,4-butylene adipate)-based polyurethane elastomer, obtained via solvent-free polymerization. This polymer possesses a combination of important advantages such as 1) low elastic modulus in the range of a few MPa, 2) good recovery ratio and 3) resilience, 4) processability, 5) nontoxicity, 6) biocompatibility, and 7) biodegradability that makes it suitable for fabrication of structures mimicking extracellular matrix of muscle tissue. Touch spinning allows fast and precise deposition of highly aligned micro- and nano-fibers without use of high voltage. C2C12 myoblasts readily align along soft polymer fibers and demonstrate high viability as well as proliferation that make proposed combination of polymer and fabrication method highly suitable for engineering skeletal muscles.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biofabrication; microfibers; poly(ester-urethane); skeletal muscles; touchspinning
Institutions of the University: Faculties > Faculty of Engineering Science > Professor Biofabrication
Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Faculties > Faculty of Engineering Science
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 19 Jan 2022 10:04
Last Modified: 29 Sep 2022 06:28
URI: https://eref.uni-bayreuth.de/id/eprint/68416