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Pristine and artificially-aged polystyrene microplastic particles differ in regard to cellular response

Title data

Völkl, Matthias ; Jérôme, Valérie ; Weig, Alfons ; Jasinski, Julia ; Meides, Nora ; Strohriegl, Peter ; Scheibel, Thomas ; Freitag, Ruth:
Pristine and artificially-aged polystyrene microplastic particles differ in regard to cellular response.
In: Journal of Hazardous Materials. Vol. 435 (2022) . - No. 128955.
ISSN 0304-3894
DOI: https://doi.org/10.1016/j.jhazmat.2022.128955

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft
SFB 1357 – 391977956

Abstract in another language

Microplastic particles (MP), arising from the gradual decomposition of plastics in the environment, have been identified as a global problem. Most investigations of MP cytotoxicity use pristine spherical particles available from commercial sources when evaluating their impact on mammalian cells, while only limited data is available for the more relevant “weathered microplastic”. In this study, we exposed murine macrophages to polystyrene MP either after up to 130 days of accelerated ageing or in pristine condition. Weathered and pristine MP were physicochemically characterized, and their cytotoxicity was investigated using biological assays, transcriptome analysis, and metabolic pathways prediction. Whereas the response to pristine MP is mainly dominated by a TNF-α release, sharp-edged weathered MP induce broader adverse cellular reactions. This study stresses the importance of including more realistic test particles (e.g., weathered particles) in combination with a broad range of biological assays when evaluating the potential risk of microplastic exposure.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Weathered particles; Inflammation; Microplastic; Nanoplastic
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Research Institutions > Collaborative Research Centers, Research Unit > SFB 1357 - MIKROPLASTIK
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Faculties > Faculty of Engineering Science > Chair Biomaterials
Research Institutions
Research Institutions > Collaborative Research Centers, Research Unit
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 25 Apr 2022 11:33
Last Modified: 05 Jul 2022 13:26
URI: https://eref.uni-bayreuth.de/id/eprint/69349