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Dimethylmonothioarsenate Is Highly Toxic for Plants and Readily Translocated to Shoots

Title data

Pischke, Erik ; Barozzi, Fabrizio ; Colina Blanco, Andrea Ester ; Kerl, Carolin ; Planer-Friedrich, Britta ; Clemens, Stephan:
Dimethylmonothioarsenate Is Highly Toxic for Plants and Readily Translocated to Shoots.
In: Environmental Science & Technology. Vol. 56 (2022) Issue 14 . - pp. 10072-10083.
ISSN 0013-936X
DOI: https://doi.org/10.1021/acs.est.2c01206

Abstract in another language

Arsenic is one of the most relevant environmental pollutants and human health threats. Several arsenic species occur in soil pore waters. Recently, it was discovered that these include inorganic and organic thioarsenates. Among the latter, dimethylmonothioarsenate (DMMTA) is of particular concern because in mammalian cells, its toxicity was found to exceed even that of arsenite. We investigated DMMTA toxicity for plants in experiments with Arabidopsis thaliana and indeed observed stronger growth inhibition than with arsenite. DMMTA caused a specific, localized deformation of root epidermal cells. Toxicity mechanisms apparently differ from those of arsenite since no accumulation of reactive oxygen species was observed in DMMTA-exposed root tips. Also, there was no contribution of the phytochelatin pathway to the DMMTA detoxification as indicated by exposure experiments with respective mutants and thiol profiling. RNA-seq analysis found strong transcriptome changes dominated by stress-responsive genes. DMMTA was taken up more efficiently than the methylated oxyarsenate dimethylarsenate and highly mobile within plants as revealed by speciation analysis. Shoots showed clear indications of DMMTA toxicity such as anthocyanin accumulation and a decrease in chlorophyll and carotenoid levels. The toxicity and efficient translocation of DMMTA within plants raise important food safety issues.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Earth Sciences > Professor Environmental Geochemistry Group
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Earth Sciences > Professor Environmental Geochemistry Group > Professor Environmental Geochemistry - Univ.-Prof. Dr. Britta Planer-Friedrich
Research Institutions > Research Centres > Bayreuth Center of Ecology and Environmental Research- BayCEER
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 550 Earth sciences, geology
Date Deposited: 20 Jul 2022 07:59
Last Modified: 20 Jul 2022 10:32
URI: https://eref.uni-bayreuth.de/id/eprint/70676