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Controlled Hierarchical Assembly of Spider Silk-DNA Chimeras into Ribbons and Raft-Like Morphologies

Title data

Humenik, Martin ; Drechsler, Markus ; Scheibel, Thomas:
Controlled Hierarchical Assembly of Spider Silk-DNA Chimeras into Ribbons and Raft-Like Morphologies.
In: Nano Letters. Vol. 14 (July 2014) Issue 7 . - pp. 3999-4004.
ISSN 1530-6992
DOI: https://doi.org/10.1021/nl501412k

Official URL: Volltext

Abstract in another language

Spider silk–DNA conjugates comprising the recombinant spider silk protein eADF4(C16) and short oligonucleotides were arranged in a linear antiparallel and parallel as well as in a branched manner via designed complementarity of the DNA moieties. After cross-β fibril self-assembly, temperature-induced annealing of the DNA moieties triggered fibril association into ribbons, composed of aligned nanofibrils, and rafts composed of ribbons ordered into sharply bordered, squared fibrous microstructures. The formation of the superstructures was clearly dependent on the individual silk–DNA conjugate. A combination of 5′-conjugated silk moieties via complementary nucleic acids enhanced fibril association, whereas mixing complementary 5′- and 3′-silk conjugates inhibited the formation of higher-order structures.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Assembly; conjugates; DNA; fibril; spider silk
Institutions of the University: Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Research Institutions > Research Centres > Bayreuth Institute of Macromolecular Research - BIMF
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Research Institutions > Research Centres > Research Center for Bio-Macromolecules - BIOmac
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Faculties
Faculties > Faculty of Engineering Science > Chair Biomaterials
Research Institutions
Research Institutions > Research Centres
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 03 Mar 2015 15:04
Last Modified: 26 Nov 2015 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/7763