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Engineering of Recombinant Spider Silk Proteins Allows Defined Uptake and Release of Substances

Title data

Doblhofer, Elena ; Scheibel, Thomas:
Engineering of Recombinant Spider Silk Proteins Allows Defined Uptake and Release of Substances.
In: Journal of Pharmaceutical Sciences. Vol. 104 (March 2015) Issue 3 . - pp. 988-994.
ISSN 1520-6017
DOI: https://doi.org/10.1002/jps.24300

Official URL: Volltext

Abstract in another language

Drug delivery carriers stabilize drugs and control their release, expanding the therapeutic window, and avoiding side effects of otherwise freely diffusing drugs in the human body. Materials used as carrier vehicles have to be biocompatible, biodegradable, nontoxic, and nonimmunogenic. Previously, particles made of the recombinant spider silk protein eADF4(C16) could be effectively loaded
with positively and neutrally charged model substances. Here, a new positively charged variant thereof, named eADF4(κ16), has been engineered. Its particle formation is indistinguishable to that of polyanionic eADF4(C16), but in contrast polycationic eADF4(κ16) allows incorporation of negatively charged substances. Both high-molecular-weight substances, such as nucleic acids, and low-molecular-weight
substances could be efficiently loaded onto eADF4(κ16) particles, and release of nucleic acids was shown to be well controlled. © 2014
Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:988–994, 2015

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biodegradable polymers; biomaterials; biotechnology; DNA/oligonucleotide delivery; drug delivery system
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Research Institutions > Research Centres > Research Center for Bio-Macromolecules - BIOmac
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Research Institutions
Research Institutions > Research Centres
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 04 Mar 2015 10:25
Last Modified: 26 Nov 2015 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/7864