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Essential Cdk1-inhibitory role for separase during meiosis I in vertebrate oocytes

Title data

Gorr, Ingo H. ; Reis, Alexandra ; Boos, Dominik ; Wühr, Martin ; Madgwick, Suzanne ; Jones, Keith T. ; Stemmann, Olaf:
Essential Cdk1-inhibitory role for separase during meiosis I in vertebrate oocytes.
In: Nature Cell Biology. Vol. 8 (8 September 2006) . - pp. 1035-1037.
ISSN 1476-4679
DOI: https://doi.org/10.1038/ncb1467

Official URL: Volltext

Abstract in another language

Separase not only triggers anaphase of meiosis I by proteolytic cleavage of cohesin on chromosome arms, but in vitro vertebrate separase also acts as a direct inhibitor of cyclin-dependent kinase 1 (Cdk1) on liberation from the inhibitory protein, securin. Blocking separase-Cdk1 complex formation by microinjection of anti-separase antibodies prevents polar-body extrusion in vertebrate oocytes. Importantly, proper meiotic maturation is rescued by chemical inhibition of Cdk1 or expression of Cdk1-binding separase fragments lacking cohesin-cleaving activity.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics > Chair Genetics - Univ.-Prof. Dr. Olaf Stemmann
Profile Fields > Advanced Fields > Molecular Biosciences
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 26 Mar 2015 11:35
Last Modified: 26 Mar 2015 11:35
URI: https://eref.uni-bayreuth.de/id/eprint/8546