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Controlled antibody/(bio-) conjugation of inorganic nanoparticles for targeted delivery

Titelangaben

Montenegro, Jose-Maria ; Grazu, Valeria ; Sukhanova, Alyona ; Agarwal, Seema ; de la Fuente, Jesus M. ; Nabiev, Igor ; Greiner, Andreas ; Parak, Wolfgang J.:
Controlled antibody/(bio-) conjugation of inorganic nanoparticles for targeted delivery.
In: Advanced Drug Delivery Reviews. Bd. 65 (Mai 2013) Heft 5 . - 677 - 688.
ISSN 0169-409X
DOI: https://doi.org/10.1016/j.addr.2012.12.003

Volltext

Link zum Volltext (externe URL): Volltext

Angaben zu Projekten

Projektfinanzierung: European Comission, Grant-Number NMP-2009-4.0-3-246479; ERC; MEGA-grant of the Ministry of High Education and Science of the Russian Federation, Grant-Number 11.G3431.0050

Abstract

Abstract Arguably targeting is one of the biggest problems for controlled drug delivery. In the case that drugs can be directed with high efficiency to the target tissue, side effects of medication are drastically reduced. Colloidal inorganic nanoparticles (NPs) have been proposed and described in the last 10 years as new platforms for in vivo delivery. However, though {NPs} can introduce plentiful functional properties (such as controlled destruction of tissue by local heating or local generation of free radicals), targeting remains an issue of intense research efforts. While passive targeting of {NPs} has been reported (the so-called enhanced permeation and retention, {EPR} effect), still improved active targeting would be highly desirable. One classical approach for active targeting is mediated by molecular recognition via capture molecules, i.e. antibodies (Abs) specific for the target. In order to apply this strategy for NPs, they need to be conjugated with Abs against specific biomarkers. Though many approaches have been reported in this direction, the controlled bioconjugation of {NPs} is still a challenge. In this article the strategies of controlled bioconjugation of {NPs} will be reviewed giving particular emphasis to the following questions: 1) how can the number of capture molecules per {NP} be precisely adjusted, and 2) how can the Abs be attached to {NP} surfaces in an oriented way. Solution of both questions is a cornerstone in controlled targeting of the inorganic {NPs} bioconjugates. (C) 2013 Elsevier B.V. All rights reserved.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Zusätzliche Informationen: Inorganic nanoparticle platforms
Keywords: Colloidal nanoparticles; Quantum dots; Gold nanoparticles; Magnetic nanoparticles; Antibodies; Drug delivery; Bioconjugation; Molecular recognition; Controlled targeting
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II > Lehrstuhl Makromolekulare Chemie II - Univ.-Prof. Dr. Andreas Greiner
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
600 Technik, Medizin, angewandte Wissenschaften > 600 Technik
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
Eingestellt am: 23 Mär 2015 08:21
Letzte Änderung: 31 Mär 2015 08:49
URI: https://eref.uni-bayreuth.de/id/eprint/9128