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Electrospinning and cutting of ultrafine bioerodible poly(lactide-co-ethylene oxide) tri- and multiblock copolymer fibers for inhalation applications

Title data

Thieme, Marcel ; Agarwal, Seema ; Wendorff, Joachim H. ; Greiner, Andreas:
Electrospinning and cutting of ultrafine bioerodible poly(lactide-co-ethylene oxide) tri- and multiblock copolymer fibers for inhalation applications.
In: Polymers for Advanced Technologies. Vol. 22 (September 2011) Issue 9 . - pp. 1335-1344.
ISSN 1099-1581
DOI: https://doi.org/10.1002/pat.1617

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Triblock copolymers made up of poly(ethylene oxide) (PEO) and polylactide (PLA) were synthesized and converted to fibers by the electrospinning process. A two-step in situ-synthesis in bulk was applied to extend PLA-PEO-PLA triblock copolymers with relatively short block length and low molecular weight in order to obtain electrospinnable materials. DL-lactide was polymerized to the hydroxyl chain ends of PEO via the stannous octoate route. Hexamethylene diisocyanate (HDI) was added as chain extender in the second step, leading to poly(ether-ester-urethane) multiblock copolymers. The materials were electrospun from solutions in chloroform. Different concentrations and voltages were analyzed. The ether and ester blocks were varied in their block length and their effects on the fiber morphology was studied. Variations in the electrical conductivity of the chloroform solutions were investigated by adding triethyl benzyl ammonium chloride (TEBAC) in different amounts. Finally, with high quality electrospun PLA-PEO-PEO triblock copolymer fibers mechanical cutting was possible. Copyright (C) 2009 John Wiley & Sons, Ltd.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: electrospinning; cut fibers; multiblock copolymers
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 06:17
Last Modified: 01 Apr 2015 06:17
URI: https://eref.uni-bayreuth.de/id/eprint/9537