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In Vitro Study of Dexamethasone Release From Poly(p-xylylene) Films

Title data

Hanefeld, Phillip ; Agarwal, Seema ; Kumar, Rakesh ; Greiner, Andreas:
In Vitro Study of Dexamethasone Release From Poly(p-xylylene) Films.
In: Macromolecular Chemistry and Physics. Vol. 211 (19 January 2010) Issue 2 . - pp. 265-269.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.200900537

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft
SCS

Abstract in another language

Stents or metal endoprotheses are currently used to prevent restenosis after percutaneous transluminal angioplasty (PTA). Recently multi-component systems comprising implant applications, e. g., stents, protective and/or a drug containing layers, have found wide-spread application. Permanent and biocompatible stent coatings based on polyp-xylylene) (PPX) films were investigated for their potential to form drug containing reservoirs. The model drug dexamethasone was loaded into films of PPX by solvent treatment. Loading efficiency and in vitro drug release profiles were studied under physiological conditions. Linear release of dexamethasone was observed when PPX/dexamethasone films were coated by an additional PPX film as cover layer.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: dexamethasone; drug release; parylene; PPX; stent
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 09:54
Last Modified: 01 Apr 2015 09:54
URI: https://eref.uni-bayreuth.de/id/eprint/9560